Commentary---QT prolongation due to roxithromycin

QT prolongation due to roxithromycin.

Roxithromycin and other macrolide antimicrobials are widely used for a broad variety of infections such as upper respiratory tract infection and community acquired pneumonia. Prolongation of the QT interval, torsade de pointes polymorphic ventricular tachycardia, and sudden death are well described but little known adverse reactions common to all macrolides. We report the case of a 72 year old ...

ADVERSE DRUG REACTION QT prolongation due to roxithromycin

Roxithromycin and other macrolide antimicrobials are widely used for a broad variety of infections such as upper respiratory tract infection and community acquired pneumonia. Prolongation of the QT interval, torsade de pointes polymorphic ventricular tachycardia, and sudden death are well described but little known adverse reactions common to all macrolides. We report the case of a 72 year old ...

QT Prolongation due to Graves' Disease

Hyperthyroidism is a highly prevalent disease affecting over 4 million people in the US. The disease is associated with many cardiac complications including atrial fibrillation and also less commonly with ventricular tachycardia and fibrillation. Many cardiac pathologies have been extensively studied; however, the relationship between hyperthyroidism and rate of ventricular repolarization manif...

Medicines and QT Prolongation

Drug induced QT prolongation.

The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...